Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 6/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | PDE6D | O43924 | 2/20 | 0.33 |
| ▸ | PDE6A | P16499 | 2/20 | 0.33 |
| ▸ | PDE6G | P18545 | 2/20 | 0.33 |
| ▸ | PDE6B | P35913 | 2/20 | 0.33 |
| ▸ | PDE6C | P51160 | 2/20 | 0.33 |
| ▸ | PDE6H | Q13956 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31026800 | 1.00 | MAT2A (0.39) | MAT2ASCN9APDE2APDE10APDE6D | |
| SCHEMBL30420838 | 0.88 | MAT2A (0.41) | MAT2APDE10AKDM4E | |
| SCHEMBL26093155 | 0.88 | MAT2A (0.41) | MAT2APDE10AKDM4E | |
| SCHEMBL26091783 | 0.87 | MAT2A (0.41) | MAT2APDE2APDE10APDE6DPDE6A | |
| SCHEMBL30420438 | 0.87 | MAT2A (0.41) | MAT2APDE2APDE10APDE6DPDE6A | |
| SCHEMBL26485128 | 0.86 | MAT2A (0.50) | MAT2ASCN9APDE10ALMNAL3MBTL1 | |
| SCHEMBL30418873 | 0.86 | MAT2A (0.50) | MAT2ASCN9APDE10ALMNAL3MBTL1 | |
| SCHEMBL30420280 | 0.85 | MAT2A (0.35) | MAT2ASCN9APDE2APDE10APDE6D | |
| SCHEMBL26091386 | 0.85 | MAT2A (0.35) | MAT2ASCN9APDE2APDE10APDE6D | |
| SCHEMBL30419914 | 0.83 | MAT2A (0.40) | MAT2ASCN9APDE2APDE10APDE6D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999713-B2 | Methionine adenosyltransferase 2a (MAT2A) inhibitors and uses thereof | INSILICO MEDICINE IP LIMITED (HK) | 2024-06-04 | — | — | US | disclosed |
| US-20240132465-A1 | METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITORS AND USES THEREOF | INSILICO MEDICINE LTD. (CN) | 2024-04-25 | — | — | US | disclosed |
| WO-2023066283-A1 | METHIONINE ADENOSYLTRANSFERASE 2A (MAT2A) INHIBITORS AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999713-B2 | Methionine adenosyltransferase 2a (MAT2A) inhibitors and uses thereof | MAT2A, MAT2B, MAT1A | MAT2A 1/4885SCN9A 3737/4885PDE2A 555/4885 |
| US-20240132465-A1 | METHIONINE ADENOSYLTRANSFERASE 2a (MAT2A) INHIBITORS AND USES THEREOF | MAT2A, MAT2B, MAT1A | MAT2A 1/4885SCN9A 3737/4885PDE2A 555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.