Ercalcitriol

Ercalcitriol

SCHEMBL264875

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nearest known ligand 0.80

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VDR P11473 12/20 0.80
ADORA3 P0DMS8 3/20 0.78
SLC6A2 P23975 3/20 0.78
NR1I2 O75469 2/20 0.78
PGR P06401 2/20 0.78
SLC6A4 P31645 2/20 0.78
ADRA1A P35348 2/20 0.78
PTGS2 P35354 2/20 0.78
HTR1A P08908 1/20 0.78
MAPT P10636 2/20 0.71
AGTR1 P30556 2/20 0.71
ABCB11 O95342 1/20 0.71
GC P02774 1/20 0.71
RXRA P19793 1/20 0.71
CHRM3 P20309 1/20 0.71
CNR1 P21554 1/20 0.71
HTR2C P28335 1/20 0.71
MAPK1 P28482 1/20 0.71
OPRD1 P41143 1/20 0.71
OPRK1 P41145 1/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ercalcitriol SCHEMBL12922723 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL17274136 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL4393978 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL264876 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL4398182 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL23142603 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL8776000 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL9050396 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL21433255 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR
Ercalcitriol SCHEMBL17274137 1.00 VDR (0.80) VDRADORA3SLC6A2NR1I2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1350 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698162-A1 TREATMENT OF HYPOPARATHYROIDISM USING TRIPHENYL CALCILYTIC COMPOUNDS Calcilytix Therapeutics, Inc. (US) 2026-02-25 EP claimed
EP-4676955-A2 HUMAN FGF23-BINDING ANTIBODIES WITH IMPROVED AFFINITY AND EFFICACY Ultragenyx Pharmaceutical Inc. (US) 2026-01-14 EP claimed
WO-2025122686-A1 COMPOSITIONS AND METHODS FOR TREATING OBESITY YALE UNIVERSITY (US) 2025-06-12 WO claimed
WO-2025108575-A1 METHODS OF SELECTIVE DEPROTECTION AND SYNTHESIS OF TRANSHYDRINDANE- SKELETON-BASED COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2025-05-30 WO claimed
CN-119909083-A Application of vitamin D and derivatives thereof in preparation of products for preventing and/or treating intestinal aging 仙乐健康科技股份有限公司 2025-05-02 CN claimed
CN-119322137-A Liquid chromatography tandem mass spectrometry detection method for serum vitamin D metabolic pathway metabolites 凯莱谱科技股份有限公司 2025-01-17 CN claimed
US-20240351033-A1 COMPOSITIONS, DEVICES, AND METHODS OF MITIGATING LIPOPROTEIN INTERFERENCE IN IN VITRO DIAGNOSTIC ASSAYS FOR HYDROPHOBIC ANALYTES SIEMENS HEALTHCARE DIAGNOSTICS INC. (US) 2024-10-24 US claimed
WO-2024220796-A1 TREATMENT OF HYPOPARATHYROIDISM USING TRIPHENYL CALCILYTIC COMPOUNDS CALCILYTIX THERAPEUTICS, INC. (US) 2024-10-24 WO claimed
EP-3851114-B1 COMPOSITION COMPRISING MICELLAR WHEY PROTEIN, VITAMIN D AND CALCIUM FOR USE IN DECREASING FAT DEPOSITION IN SKELETAL MUSCLE IN AN ELDERLY INDIVIDUAL NESTLE SA (CH) 2024-10-09 EP claimed
WO-2024191781-A2 HUMAN FGF23-BINDING ANTIBODIES WITH IMPROVED AFFINITY AND EFFICACY ULTRAGENYX PHARMACEUTICAL INC. (US) 2024-09-19 WO claimed
EP-0401357-A1 METHOD FOR IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS. WISCONSIN ALUMNI RES FOUND (US) 1990-12-12 EP claimed
WO-1990006121-A2 METHOD FOR IMPROVING REPRODUCTIVE FUNCTIONS IN MAMMALS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1990-06-14 WO claimed
EP-0337305-A1 Process for the preparation of 1-alpha,25-dihydroxy-vitamin D2 and the 24-epimer thereof NISSHIN FLOUR MILLING CO., LTD. (JP) 1989-10-18 EP claimed
US-4749710-A HYDROXYLATED ERGOCALCIFEROLS; ADMINISTERING HOFFMANN-LA ROCHE INC. (US) 1988-06-07 US claimed
EP-0198901-A4 METHOD FOR PREPARING 1ALPHA-HYDROXYVITAMIN D COMPOUNDS. WISCONSIN ALUMNI RES FOUND (US) 1987-03-09 EP claimed
EP-0198901-A1 METHOD FOR PREPARING 1ALPHA-HYDROXYVITAMIN D COMPOUNDS. WISCONSIN ALUMNI RES FOUND (US) 1986-10-29 EP claimed
WO-1986002648-A1 METHOD FOR PREPARING 1alpha-HYDROXYVITAMIN D COMPOUNDS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1986-05-09 WO claimed
US-4508651-A Synthesis of 1α,25-dihydroxyergocalciferol HOFFMANN-LA ROCHE INC. (US) 1985-04-02 US claimed
WO-1984004527-A1 PROCESS FOR THE PREPARATION OF 1alpha,25-DIHYDROXYLATED VITAMIN D2 AND RELATED COMPOUNDS WISCONSIN ALUMNI RES FOUND (US) 1984-11-22 WO claimed
EP-0122490-A2 Process for the preparation of 1-alpha, 25-dihydroxy ergocalciferol F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1984-10-24 EP claimed