Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.54 |
| ▸ | USP7 | Q93009 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | NEK2 | P51955 | 1/20 | 0.54 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | STAT1 | P42224 | 1/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 2/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646435 | 0.79 | CNR1 (0.63) | FYNCHEK1USP7FGFR1NEK2 | |
| SCHEMBL11232425 | 0.78 | FYN (0.58) | FYNCHEK1USP7FGFR1NEK2 | |
| SCHEMBL3786463 | 0.76 | NQO2 (0.73) | NPC1RAB9ASMN1; SMN2TP53NQO2 | |
| SCHEMBL8577619 | 0.75 | SMN1; SMN2 (0.70) | NPC1RAB9ASMN1; SMN2TP53NQO2 | |
| SCHEMBL11222723 | 0.75 | CNR1 (0.64) | FYNNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL10663620 | 0.74 | CYP17A1 (0.76) | FYNNPC1RAB9ASMN1; SMN2NQO2 | |
| SCHEMBL3242870 | 0.74 | BRAF (0.62) | FYNCHEK1USP7FGFR1NEK2 | |
| SCHEMBL12821681 | 0.74 | CHEK1 (0.69) | FYNCHEK1USP7FGFR1NEK2 | |
| SCHEMBL11227834 | 0.74 | CYP17A1 (0.56) | CHEK1FGFR1NEK2MAPK15NPC1 | |
| SCHEMBL13680541 | 0.73 | HSD17B10 (0.79) | NPC1RAB9ASMN1; SMN2NQO2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902813-A | MODULATORS OF THE BENZODIAXEPINE RECEPTOR OT THE GAMMA-BUTYRIC ACID(A) RECEPTOR COMPLEX; ANXIOLYTIC, ANTIEPILEPTIC AND -CONVULSANT AGENTS; SLEEP AND MEMORY DISORDERS | NEUROSEARCH A/S (DK) | 1999-05-11 | — | — | US | disclosed |
| EP-0821683-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033192-A1 | BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 1996-10-24 | — | — | WO | disclosed |