Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649209 | 0.78 | FABP4 (0.44) | PPARGFFAR1DHODHFABP4FABP5 | |
| SCHEMBL29812216 | 0.76 | FFAR1 (0.38) | PPARGFFAR1DHODHPOLBESR1 | |
| SCHEMBL23147157 | 0.76 | FFAR1 (0.38) | PPARGFFAR1DHODHPOLBESR1 | |
| SCHEMBL4520339 | 0.75 | KDM4E (0.44) | METAP2DHODH | |
| SCHEMBL29764820 | 0.72 | ALK (0.43) | PPARGFFAR1DHODHPOLBESR1 | |
| SCHEMBL23147361 | 0.72 | ALK (0.43) | PPARGFFAR1DHODHPOLBESR1 | |
| SCHEMBL27362528 | 0.72 | MRGPRX4 (0.43) | PPARGFFAR1MRGPRX4MAPK14FABP4 | |
| SCHEMBL27537115 | 0.71 | MEN1 (0.50) | METAP2POLB | |
| SCHEMBL9672293 | 0.70 | KEAP1 (0.52) | PPARGFFAR1FABP4FABP5 | |
| SCHEMBL12603795 | 0.70 | PTGS1 (0.43) | PPARGFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |
| EP-0934274-A1 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | Bayer Corporation (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998004528-A2 | SUBSTITUTED PYRIDINES AND BIPHENYLS AS ANTI-HYPERCHOLESTERINEMIC, ANTI-HYPERLIPOPROTEINEMIC AND ANTI-HYPERGLYCEMIC AGENTS | BAYER CORPORATION (US) | 1998-02-05 | — | — | WO | disclosed |