Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 1.00 |
| ▸ | VCP | P55072 | 3/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.69 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.69 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.69 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.69 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7246864 | 0.88 | ALOX5 (0.79) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL31126428 | 0.88 | ALOX5 (0.78) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL1888054 | 0.87 | ALOX5 (0.78) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL23610351 | 0.86 | ALOX5 (0.76) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL1822809 | 0.86 | ALOX5 (0.76) | ALOX5VCPMAPTMEN1KMT2A | |
| SCHEMBL7112167 | 0.86 | ALOX5 (0.75) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL23539595 | 0.85 | ALOX5 (0.73) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL23553570 | 0.85 | VCP (1.00) | ALOX5VCPMAPTMEN1KMT2A | |
| SCHEMBL1887335 | 0.84 | ESR1 (1.00) | ALOX5VCPESR1MAPTMEN1 | |
| SCHEMBL12157973 | 0.84 | ALOX5 (0.73) | ALOX5VCPESR1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107629022-B | Antibacterial synergist and preparation method and application thereof | 上海医药工业研究院 | 2024-11-12 | — | — | CN | disclosed |
| US-20050256175-A1 | Novel glucagon antagonists/inverse agonists | LAU JESPER | 2005-11-17 | — | — | US | disclosed |
| US-6881746-B2 | Glucagon antagonists/inverse agonists | NOVO NORDICK A/S (DK) | 2005-04-19 | — | — | US | disclosed |
| EP-1519723-A1 | NOVEL GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2005-04-06 | — | — | EP | disclosed |
| US-20040014789-A1 | Novel glucagon antagonists/inverse agonists | NOVO NORDISK A/S (DK) | 2004-01-22 | — | — | US | disclosed |
| WO-2004002480-A1 | NOVEL GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014789-A1 | Novel glucagon antagonists/inverse agonists | GLP1R, GCGR, GIPR | ALOX5 4481/4885VCP 1768/4885ESR1 594/4885 |
| US-20050256175-A1 | Novel glucagon antagonists/inverse agonists | GLP1R, GCGR, GIPR | ALOX5 4481/4885VCP 1768/4885ESR1 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.