Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | THRB | P10828 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | VDR | P11473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650789 | 0.92 | GCK (0.36) | GCKKMT2AL3MBTL1 | |
| SCHEMBL2651148 | 0.83 | GCK (0.35) | GCKKMT2A | |
| SCHEMBL2650928 | 0.82 | TAS1R3 (0.32) | — | |
| SCHEMBL2650347 | 0.82 | GCK (0.34) | GCKKMT2A | |
| SCHEMBL2649681 | 0.82 | GCK (0.34) | GCKKMT2A | |
| SCHEMBL2650499 | 0.81 | GCK (0.35) | GCK | |
| SCHEMBL2649950 | 0.80 | TAS1R3 (0.34) | — | |
| SCHEMBL2645570 | 0.80 | GCK (0.40) | GCKVCAM1KMT2ATHRBPPARG | |
| SCHEMBL2645574 | 0.80 | GCK (0.40) | GCKVCAM1KMT2ATHRBPPARG | |
| SCHEMBL2645675 | 0.76 | CNR2 (0.39) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311504-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014312-A1 | TETRAZOLYL-PHENYL ACETAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |