SCHEMBL2649653

SCHEMBL2649653

CC(=O)c1ccc2nc(-c3cccc(Br)c3)[nH]c2c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 4/20 0.76
HDAC3 O15379 2/20 0.76
HDAC1 Q13547 2/20 0.76
HDAC8 Q9BY41 2/20 0.76
HDAC2 Q92769 1/20 0.76
MMP13 P45452 4/20 0.57
MMP2 P08253 3/20 0.57
MMP9 P14780 3/20 0.57
MMP8 P22894 3/20 0.57
MEN1 O00255 4/20 0.57
KMT2A Q03164 4/20 0.57
KDM4E B2RXH2 3/20 0.57
ALDH1A1 P00352 2/20 0.57
POLB P06746 2/20 0.57
TP53 P04637 1/20 0.57
HPGD P15428 1/20 0.57
HSD17B10 Q99714 1/20 0.57
CHEK2 O96017 4/20 0.55
SIRT2 Q8IXJ6 1/20 0.53
NPBWR1 P48145 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2649652 0.90 HDAC6 (0.61) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL2341761 0.88 HDAC6 (0.77) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL18229615 0.86 HDAC6 (1.00) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL19982678 0.85 CHEK2 (0.74) HDAC6HDAC3HDAC1HDAC8MEN1
SCHEMBL6450749 0.82 NPBWR1 (0.71) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL19986735 0.81 CYP1A2 (0.59) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL17672255 0.79 KDM4E (0.77) MMP13MMP2MMP9MMP8MEN1
SCHEMBL2341758 0.78 KDM4E (0.64) HDAC6HDAC3HDAC1HDAC8HDAC2
SCHEMBL19753931 0.77 CHEK2 (0.67) MMP13MMP2MMP9MMP8MEN1
SCHEMBL30726509 0.77 CYP11B1 (0.62) HDAC6HDAC3HDAC1HDAC8HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0821682-B1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA-A RECEPTOR COMPLEX NEUROSEARCH AS (DK) 2000-07-19 EP disclosed
US-5922725-A Benzimidazole compounds and their use as modulators of the GABAA receptor complex NEUROSEARCH A/S (DK) 1999-07-13 US disclosed
EP-0821682-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABA A? RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1998-02-04 EP disclosed
WO-1996033191-A1 BENZIMIDAZOLE COMPOUNDS AND THEIR USE AS MODULATORS OF THE GABAA RECEPTOR COMPLEX NEUROSEARCH A/S (DK) 1996-10-24 WO disclosed