Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.49 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.44 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.44 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652195 | 0.92 | NPC1 (0.54) | ADORA2AAGERMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL2650774 | 0.87 | MAPT (0.59) | ADORA2AAGERMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL2659242 | 0.82 | LMNA (0.49) | MAPTSMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL2650059 | 0.80 | GCK (0.66) | ADORA2AAGERMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL2653570 | 0.79 | LMNA (0.45) | MAPTSMN1; SMN2HSD17B10LMNAXBP1 | |
| SCHEMBL2651594 | 0.77 | GCK (0.48) | SMN1; SMN2HSD17B10LMNAXBP1MEN1 | |
| SCHEMBL2662039 | 0.76 | LMNA (0.45) | ADORA2ASMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2661212 | 0.76 | GCK (0.48) | SMN1; SMN2NPC1RAB9ALMNACYP2C19 | |
| SCHEMBL2661654 | 0.75 | GCK (0.48) | SMN1; SMN2NPC1RAB9ALMNAXBP1 | |
| SCHEMBL2654208 | 0.74 | GCK (0.47) | SMN1; SMN2NPC1RAB9ALMNAXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283830-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001085707-A1 | PARA-AMINE SUBSTITUTED PHENYLAMIDE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | disclosed |