Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 3/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650231 | 1.00 | PPIA (0.40) | PPIAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL2650419 | 0.91 | PPIA (0.41) | PPIAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL2648334 | 0.89 | PTGER1 (0.45) | PPIAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL2650426 | 0.81 | GCGR (0.43) | PTGER1PTGER4PTGER3PTGER2MCL1 | |
| SCHEMBL2650428 | 0.79 | BRD4 (0.37) | PTGER1PTGER4PTGER3PTGER2MCL1 | |
| SCHEMBL2649451 | 0.76 | LMNA (0.44) | MEN1HSP90AA1KMT2AMCL1ALDH1A1 | |
| SCHEMBL2647297 | 0.76 | LMNA (0.44) | MEN1HSP90AA1KMT2AMCL1ALDH1A1 | |
| SCHEMBL2648920 | 0.75 | LMNA (0.54) | MEN1HSP90AA1KMT2AMCL1ALDH1A1 | |
| SCHEMBL2648908 | 0.74 | MAPT (0.39) | MEN1KMT2AMCL1ALDH1A1MAPT | |
| SCHEMBL2648905 | 0.74 | MAPT (0.39) | MEN1KMT2AMCL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218431-B1 | GLUCAGON RECEPTOR ANTAGONISTS FOR THERAPY OF DIABETES AND CONDITIONS ASSOCIATED WITH DIABETES | BAYER CORPORATION | 2001-04-17 | — | — | US | disclosed |