Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.77 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.74 |
| ▸ | MAPK13 | O15264 | 14/20 | 0.74 |
| ▸ | GCGR | P47871 | 14/20 | 0.74 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.74 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.74 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.74 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.74 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.74 |
| ▸ | FRK | P42685 | 4/20 | 0.74 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.74 |
| ▸ | GSK3B | P49841 | 4/20 | 0.74 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.74 |
| ▸ | PTK6 | Q13882 | 3/20 | 0.74 |
| ▸ | PRKD2 | Q9BZL6 | 3/20 | 0.74 |
| ▸ | PRKACA | P17612 | 3/20 | 0.66 |
| ▸ | SLK | Q9H2G2 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553131 | 0.87 | ALOX5 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL19868925 | 0.86 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL15075603 | 0.86 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2650684 | 0.85 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL7989834 | 0.85 | MAPK11 (0.71) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2650097 | 0.84 | MAPK14 (0.78) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL2650702 | 0.83 | MAPK11 (1.00) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL5921871 | 0.83 | MAPK14 (0.72) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL6960991 | 0.83 | MAPK14 (0.72) | ALOX5MAPK11MAPK14MAPK13GCGR | |
| SCHEMBL30421799 | 0.83 | MAPK14 (0.65) | ALOX5MAPK11MAPK14MAPK13GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | claimed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | claimed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0959885-A4 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO INC (US) | 2002-07-17 | — | — | EP | disclosed |
| EP-0959885-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998022108-A1 | TRIARYL SUBSTITUTED IMIDAZOLES AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |