SCHEMBL6960991

SCHEMBL6960991

Cc1cc(C)c(-c2nc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)c(C)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 15/20 0.72
MAPK13 O15264 13/20 0.72
MAPK12 P53778 13/20 0.72
MAPK11 Q15759 13/20 0.72
GCGR P47871 12/20 0.72
CSNK1D P48730 5/20 0.68
PRKD3 O94806 3/20 0.68
MAP4K4 O95819 3/20 0.68
FRK P42685 3/20 0.68
MAPK9 P45984 3/20 0.68
CSNK1A1 P48729 3/20 0.68
GSK3B P49841 3/20 0.68
CLK4 Q9HAZ1 3/20 0.68
PTK6 Q13882 2/20 0.68
PRKD2 Q9BZL6 2/20 0.68
ALOX5 P09917 7/20 0.68
CSNK1E P49674 3/20 0.67
PRKACA P17612 2/20 0.61
SLK Q9H2G2 2/20 0.61
KDM4E B2RXH2 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5921871 1.00 MAPK14 (0.72) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL18960508 0.92 ALOX5 (0.68) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL5197068 0.91 MAPK14 (0.65) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL17002222 0.88 MAPK14 (0.76) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL5184613 0.88 MAPK14 (0.64) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL5184500 0.87 MAPK14 (0.68) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL5199659 0.85 GCGR (0.65) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL2650684 0.84 MAPK11 (1.00) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL2650680 0.83 ALOX5 (0.77) MAPK14MAPK13MAPK12MAPK11GCGR
SCHEMBL6971902 0.83 MAPK14 (0.68) MAPK14MAPK13MAPK12MAPK11GCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0797575-B1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE HOFFMANN LA ROCHE (CH) 2003-10-15 EP claimed
EP-0797575-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1997-10-01 EP claimed
WO-1996018626-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1996-06-20 WO claimed
EP-0797575-B1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE HOFFMANN LA ROCHE (CH) 2003-10-15 EP disclosed
EP-0797575-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1997-10-01 EP disclosed
WO-1996018626-A1 IMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS IN PARTICULAR EGF-R TYROSINE KINASE F. HOFFMANN-LA ROCHE AG (CH) 1996-06-20 WO disclosed