Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31923 | 0.84 | MAPT (0.43) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL31140734 | 0.82 | TSHR (0.42) | MAPTTSHRALDH1A1KDM4EGAA | |
| SCHEMBL25239223 | 0.82 | TSHR (0.42) | MAPTTSHRALDH1A1KDM4EGAA | |
| SCHEMBL754657 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL2649515 | 0.80 | MAPT (0.40) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL3560430 | 0.79 | KDM4E (0.46) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL192118 | 0.77 | MAPT (0.40) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL1341382 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL28041813 | 0.75 | KDM4E (0.41) | SMN1; SMN2MAPTNPC1NFKB1RAB9A | |
| SCHEMBL25784214 | 0.73 | TSHR (0.44) | SMN1; SMN2MAPTNPC1NFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6333336-B1 | GAMMA-AMINOBUTYRIC ACID RECEPTORS AS ANTICONVULSANTS FORMING THE COMPOUND BY AMIDATION | MERCK SHARP & DOHME LTD. (GB) | 2001-12-25 | — | — | US | disclosed |
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |