Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GCK | P35557 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343179 | 0.95 | TSHR (0.37) | SMN1; SMN2ALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL2650867 | 0.94 | POLB (0.38) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL1340920 | 0.93 | NPC1 (0.42) | SMN1; SMN2ALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL1341907 | 0.88 | TSHR (0.40) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB | |
| SCHEMBL1342650 | 0.88 | CSNK1D (0.35) | SMN1; SMN2ALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL1343278 | 0.86 | LMNA (0.39) | SMN1; SMN2NPC1RAB9APOLBTSHR | |
| SCHEMBL1343385 | 0.85 | GCK (0.37) | SMN1; SMN2ALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL1341328 | 0.84 | TSHR (0.38) | SMN1; SMN2ALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL1342862 | 0.83 | HSD17B10 (0.33) | SMN1; SMN2ALDH1A1NPC1KDM4ERAB9A | |
| SCHEMBL1339919 | 0.82 | CSNK1D (0.38) | SMN1; SMN2ALDH1A1NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |