Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GCK | P35557 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1341907 | 0.95 | TSHR (0.40) | POLBKMT2ANPC1TSHRCASP1 | |
| SCHEMBL2650833 | 0.94 | SMN1; SMN2 (0.36) | POLBKMT2ANPC1TSHRCASP1 | |
| SCHEMBL1343278 | 0.93 | LMNA (0.39) | POLBKMT2ANPC1TSHRHSD17B10 | |
| SCHEMBL1343179 | 0.88 | TSHR (0.37) | POLBKMT2ANPC1TSHRCASP1 | |
| SCHEMBL1339919 | 0.88 | CSNK1D (0.38) | POLBKMT2ANPC1TSHRCASP1 | |
| SCHEMBL1340920 | 0.86 | NPC1 (0.42) | POLBKMT2ANPC1TSHRLMNA | |
| SCHEMBL1342237 | 0.86 | CSNK1D (0.39) | POLBKMT2ANPC1TSHRLMNA | |
| SCHEMBL1342875 | 0.84 | TSHR (0.41) | POLBKMT2ANPC1TSHRCASP1 | |
| SCHEMBL1343027 | 0.83 | HSD17B10 (0.36) | POLBTSHRCASP1HSD17B10MPO | |
| SCHEMBL2651429 | 0.83 | SMN1; SMN2 (0.36) | POLBKMT2ANPC1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |