⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88351 | 0.70 | — | — | |
| SCHEMBL64580 | 0.65 | — | — | |
| SCHEMBL665488 | 0.65 | — | — | |
| SCHEMBL2629380 | 0.65 | TGFBR1 (0.43) | — | |
| SCHEMBL2659263 | 0.65 | L3MBTL1 (0.37) | — | |
| SCHEMBL25158171 | 0.64 | DYRK1A (0.37) | — | |
| SCHEMBL23697854 | 0.64 | PIK3C3 (0.35) | — | |
| SCHEMBL557100 | 0.64 | ABL1 (0.36) | — | |
| SCHEMBL5487376 | 0.64 | DYRK1A (0.40) | — | |
| SCHEMBL11266549 | 0.64 | DYRK1A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 213 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185345-A1 | Imidazo derivatives, their preparation and medicines containing them | Dr. Karl Thomae GmbH (DE) | 1986-06-25 | — | — | EP | claimed |
| WO-2025153624-A1 | IMIDAZO[1,2-D][1,2,4]TRIAZINE DERIVATIVES FOR USE AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2025-07-24 | — | — | WO | disclosed |
| WO-2025153625-A1 | IMIDAZO[1,2-D][1,2,4]TRIAZINE DERIVATIVES FOR USE AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | AC IMMUNE SA (CH) | 2025-07-24 | — | — | WO | disclosed |
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |
| WO-2022135365-A1 | DISUBSTITUTED CYCLOPENTANE KINASE INHIBITORS | ANRUI BIOMEDICAL TECHNOLOGY (GUANGZHOU) CO., LTD. (CN) | 2022-06-30 | — | — | WO | disclosed |
| US-11185531-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2021-11-30 | — | — | US | disclosed |
| US-10800743-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2020-10-13 | — | — | US | disclosed |
| EP-2970132-B1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2020-09-23 | — | — | EP | disclosed |
| US-20200289469-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2020-09-17 | — | — | US | disclosed |
| EP-1212324-B1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2003-10-29 | — | — | EP | disclosed |
| US-6608062-B1 | Ligands for gamma-aminobutyric acid receptors; treatment and/or prevention of central nervous system disorders, including anxiety | MERCK SHARP & DOHME LTD. | 2003-08-19 | — | — | US | disclosed |
| EP-1212324-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-06-12 | — | — | EP | disclosed |
| EP-1212324-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001014377-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |
| WO-2001014377-A1 | IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-03-01 | — | — | WO | disclosed |
| EP-0713876-A1 | Triazine derivative, chymase activity inhibitor and nitric oxide production inhibitor | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1996-05-29 | — | — | EP | disclosed |
| US-4716169-A | INOTROPIC AGENTS | DR. KARL THOMAE GMBH (DE) | 1987-12-29 | — | — | US | disclosed |
| EP-0185345-A1 | Imidazo derivatives, their preparation and medicines containing them | Dr. Karl Thomae GmbH (DE) | 1986-06-25 | — | — | EP | disclosed |
| US-4107309-A | ANTIASTHMATIC AGENTS, ENZYME INHIBITORS, REACTING A THIONE WITH SODIUM ETHOXIDE AND METHYL IODIDE | AMERICAN CYANAMID COMPANY (US) | 1978-08-15 | — | — | US | disclosed |