Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343337 | 0.96 | MAPK14 (0.39) | NTRK1NTRK2MAPK14MAPK13CCNE1 | |
| SCHEMBL1343374 | 0.94 | NTRK1 (0.47) | NTRK1NTRK2KDM4ESMN1; SMN2MAPK14 | |
| SCHEMBL1342391 | 0.89 | RAB9A (0.37) | KDM4ESMN1; SMN2MAPK14MAPK13LMNA | |
| SCHEMBL1342919 | 0.88 | NTRK1 (0.42) | NTRK1NTRK2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL2651283 | 0.88 | KDM4E (0.37) | NTRK1NTRK2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL1343556 | 0.81 | NTRK1 (0.43) | NTRK1NTRK2LMNAPKM | |
| SCHEMBL1343767 | 0.81 | MAPK14 (0.39) | SMN1; SMN2MAPK14MAPK13 | |
| SCHEMBL1342898 | 0.79 | MAPK14 (0.38) | NTRK1NTRK2MAPK14MAPK13 | |
| SCHEMBL1342895 | 0.78 | NTRK1 (0.55) | NTRK1NTRK2SMN1; SMN2PKM | |
| SCHEMBL1342307 | 0.78 | MAPK14 (0.40) | SMN1; SMN2MAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |