Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651280 | 0.88 | NTRK1 (0.43) | KDM4ENTRK1NTRK2CYP1A2CYP2C19 | |
| SCHEMBL1343337 | 0.83 | MAPK14 (0.39) | NTRK1NTRK2CYP2C9 | |
| SCHEMBL1343374 | 0.82 | NTRK1 (0.47) | KDM4ENTRK1POLBNTRK2CYP1A2 | |
| SCHEMBL1342391 | 0.77 | RAB9A (0.37) | KDM4EALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL1342919 | 0.76 | NTRK1 (0.42) | KDM4ENTRK1POLBNTRK2CYP1A2 | |
| SCHEMBL2649928 | 0.70 | MAPK14 (0.35) | SMN1; SMN2OGA | |
| SCHEMBL1343556 | 0.70 | NTRK1 (0.43) | NTRK1POLBNTRK2ALDH1A1CYP2C9 | |
| SCHEMBL2649750 | 0.69 | MAPT (0.35) | HTTKMT2ALMNASMN1; SMN2TP53 | |
| SCHEMBL1343767 | 0.69 | MAPK14 (0.39) | SMN1; SMN2 | |
| SCHEMBL1342898 | 0.68 | MAPK14 (0.38) | NTRK1POLBNTRK2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |