Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.50 |
| ▸ | RXRB | P28702 | 3/20 | 0.50 |
| ▸ | RXRG | P48443 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 12/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22265163 | 0.89 | DAO (0.47) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL12603784 | 0.83 | RXRA (0.55) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL2275926 | 0.83 | KIF11 (0.47) | RXRARXRBRXRGKIF11CA12 | |
| SCHEMBL1779625 | 0.79 | RXRA (0.54) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL2272131 | 0.79 | RXRA (0.50) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL3230214 | 0.79 | RXRA (0.50) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL6443956 | 0.77 | DAO (0.39) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL2652928 | 0.76 | RXRA (0.51) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL14996657 | 0.76 | RXRA (0.48) | RXRARXRBRXRGKIF11DAO | |
| SCHEMBL13756280 | 0.76 | RXRA (0.48) | RXRARXRBRXRGKIF11CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |