Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652142 | 0.83 | ESR1 (0.42) | FFAR1ESR1ADRA2AADRA2BADRA2C | |
| SCHEMBL2650946 | 0.79 | SYK (0.41) | GAAGABRA5 | |
| SCHEMBL14348152 | 0.75 | FFAR1 (0.45) | FFAR1NMT1KMT2AMEN1 | |
| SCHEMBL2650945 | 0.74 | GAA (0.46) | KMT2AHTTNPSR1GAAMEN1 | |
| SCHEMBL2651834 | 0.70 | CTSA (0.40) | CTSAESR1ADRA2AADRA2BKMT2A | |
| SCHEMBL14615243 | 0.69 | KDM4E (0.49) | FFAR1NMT1KMT2AHTTNPSR1 | |
| SCHEMBL2652007 | 0.69 | TSHR (0.43) | L3MBTL1 | |
| SCHEMBL12414712 | 0.68 | FFAR1 (0.48) | FFAR1KMT2AHTTNPSR1L3MBTL1 | |
| SCHEMBL24786379 | 0.68 | TAAR1 (0.50) | ADRA2AADRA2BADRA2CSGMS2HCAR2 | |
| SCHEMBL11709351 | 0.68 | SLC40A1 (0.39) | FFAR1ADRA2AADRA2BADRA2CSGMS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |