Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652551 | 0.88 | FFAR1 (0.41) | TSHRMAOBKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2652111 | 0.84 | IDO1 (0.41) | TSHRMAOBKDM4EALDH1A1 | |
| SCHEMBL2652142 | 0.83 | ESR1 (0.42) | MAOBKDM4ELMNA | |
| SCHEMBL2652010 | 0.83 | IDO1 (0.40) | MAOBL3MBTL1 | |
| SCHEMBL2651003 | 0.83 | IDO1 (0.40) | MAOBALDH1A1LMNAL3MBTL1 | |
| SCHEMBL2650110 | 0.80 | TP53 (0.41) | TSHRMAOBKDM4EALDH1A1 | |
| SCHEMBL2651078 | 0.80 | IDO1 (0.44) | MAOBALDH1A1 | |
| SCHEMBL2650879 | 0.79 | ALDH1A1 (0.48) | TSHRMAOBALDH1A1LMNA | |
| SCHEMBL2650061 | 0.77 | IDO1 (0.42) | TSHRMAOBKDM4EALDH1A1 | |
| SCHEMBL2650744 | 0.76 | MAPK14 (0.37) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404335-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | Astrazeneca AB (SE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003000267-A1 | AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS | ASTRAZENECA AB (SE) | 2003-01-03 | — | — | WO | disclosed |