Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494083 | 0.83 | PARP1 (0.42) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL28597691 | 0.83 | ELANE (0.40) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL7024540 | 0.81 | PARP1 (0.38) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL10624906 | 0.81 | TYMP (0.41) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL8967459 | 0.77 | KDM4E (0.43) | KDM4EALDH1A1HPGDALOX12PKM | |
| SCHEMBL1864583 | 0.77 | ELANE (0.42) | KDM4EALDH1A1HPGDALOX12MAPT | |
| SCHEMBL27459575 | 0.77 | SMN1; SMN2 (0.39) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL28988954 | 0.76 | ELANE (0.43) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL30352889 | 0.76 | ELANE (0.43) | KDM4EALDH1A1HPGDALOX12CHEK1 | |
| SCHEMBL27354265 | 0.76 | KDM4E (0.44) | KDM4EALDH1A1HPGDALOX12PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183229-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069810-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2000-11-23 | — | — | WO | disclosed |
| CN-1223659-A | Fused imidazopyridine derivatives as antihyperlipidemic agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-07-21 | — | — | CN | disclosed |