Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 13/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22074409 | 0.91 | TRPM8 (0.61) | TRPM8LMNASMN1; SMN2GAA | |
| SCHEMBL22074395 | 0.83 | TRPM8 (0.53) | TRPM8MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL22074433 | 0.82 | TRPM8 (0.52) | TRPM8LMNASMN1; SMN2NPC1TP53 | |
| SCHEMBL22074347 | 0.82 | TP53 (0.50) | TRPM8MAPTMEN1KMT2ALMNA | |
| SCHEMBL29780011 | 0.82 | TP53 (0.50) | TRPM8MAPTMEN1KMT2ALMNA | |
| SCHEMBL22074411 | 0.81 | TRPM8 (0.62) | TRPM8MAPTSMN1; SMN2TP53GAA | |
| SCHEMBL22074370 | 0.78 | NOTUM (0.53) | TRPM8MAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL7513376 | 0.77 | TRPM8 (0.58) | TRPM8MAPTMEN1KMT2ALMNA | |
| SCHEMBL18939227 | 0.73 | LMNA (0.46) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL22074391 | 0.73 | TRPM8 (0.52) | TRPM8MAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |