⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182584 | 0.76 | — | — | |
| SCHEMBL5392914 | 0.73 | NR3C2 (0.41) | — | |
| SCHEMBL4777990 | 0.73 | CHEK1 (0.37) | — | |
| SCHEMBL742490 | 0.71 | HCAR3 (0.41) | — | |
| SCHEMBL2067353 | 0.71 | — | — | |
| SCHEMBL1722107 | 0.71 | — | — | |
| SCHEMBL27453738 | 0.70 | HRH3 (0.47) | — | |
| SCHEMBL746385 | 0.70 | HCAR3 (0.43) | — | |
| SCHEMBL4777917 | 0.69 | IL1B (0.36) | — | |
| SCHEMBL5896994 | 0.69 | HRH3 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240139354-A1 | PARTICLES FUNCTIONALIZED WITH IMAGEABLE RADIOISOTOPES AND METHODS OF MAKING AND USE THEREOF | Boston Scientific Medical Device Limited (IE) | 2024-05-02 | — | — | US | disclosed |
| US-11904029-B2 | Particles functionalized with imageable radioisotopes and methods of making and use thereof | Boston Scientific Medical Device Limited (IE) | 2024-02-20 | — | — | US | disclosed |
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| US-20230117927-A1 | Targeted Radiopharmaceutical for Tumor and Its Use in the Imaging-guided Combination Therapy of Targeted Radiotherapy and Immunotherapy | BEIJING GILUNTIDE PHARMACEUTICAL CO., LTD. (CN) | 2023-04-20 | — | — | US | disclosed |
| CN-115605467-A | PHD inhibitor compounds, compositions and uses thereof | 阿克比治疗有限公司（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-115515948-A | PHD inhibitor compounds, compositions and uses | 阿克比治疗有限公司 | 2022-12-23 | — | — | CN | disclosed |
| EP-4100069-A1 | PARTICLES FUNCTIONALIZED WITH IMAGEABLE RADIOISOTOPES AND METHODS OF MAKING AND USE THEREOF | University Of Virginia Patent Foundation (US) | 2022-12-14 | — | — | EP | disclosed |
| EP-3906947-A1 | TARGETED RADIOPHARMACEUTICALS FOR TUMORS, AND COMBINATION THERAPY OF TARGETED RADIOTHERAPY THEREOF AND IMMUNOTHERAPY UNDER GUIDANCE OF IMAGES | Peking University (CN) | 2021-11-10 | — | — | EP | disclosed |
| WO-2021158611-A1 | PARTICLES FUNCTIONALIZED WITH IMAGEABLE RADIOISOTOPES AND METHODS OF MAKING AND USE THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2021-08-12 | — | — | WO | disclosed |
| US-20210236669-A1 | PARTICLES FUNCTIONALIZED WITH IMAGEABLE RADIOISOTOPES AND METHODS OF MAKING AND USE THEREOF | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2021-08-05 | — | — | US | disclosed |
| WO-2020238800-A1 | TARGETED RADIOPHARMACEUTICALS FOR TUMORS, AND COMBINATION THERAPY OF TARGETED RADIOTHERAPY THEREOF AND IMMUNOTHERAPY UNDER GUIDANCE OF IMAGES | 北京大学 | 2020-12-03 | — | — | WO | disclosed |
| US-7851490-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2010-12-14 | — | — | US | disclosed |
| EP-1877052-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2009-07-22 | — | — | EP | disclosed |
| US-20090036493-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex | ANIONA APS (DK) | 2009-02-05 | — | — | US | disclosed |
| EP-1877052-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006108800-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-19 | — | — | WO | disclosed |