Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 5/20 | 0.48 |
| ▸ | CDK7 | P50613 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.48 |
| ▸ | CCNH | P51946 | 3/20 | 0.48 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CCNK | O75909 | 2/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.48 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.48 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.37 |
| ▸ | CDK1 | P06493 | 3/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.37 |
| ▸ | CCNT2 | O60583 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18122680 | 0.85 | CDK9 (0.67) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL20549443 | 0.85 | CDK9 (0.67) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL20549440 | 0.77 | CDK9 (0.70) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL20549444 | 0.77 | CDK9 (0.70) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL18122648 | 0.77 | CDK9 (0.70) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL18122655 | 0.77 | CDK9 (0.70) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL26521561 | 0.75 | CCNT1 (0.72) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL27383991 | 0.74 | TYK2 (0.46) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL20549636 | 0.73 | CSNK2A1 (0.46) | CDK9CDK7CDK2CDK12CCNH | |
| SCHEMBL18122195 | 0.73 | CSNK2A1 (0.46) | CDK9CDK7CDK2CDK12CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3273966-B1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | DANA FARBER CANCER INST INC (US) | 2023-05-03 | — | — | EP | disclosed |