Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565010 | 0.97 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL2653273 | 0.83 | MAPT (0.50) | SMN1; SMN2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL1565635 | 0.82 | NPC1 (0.50) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL2653444 | 0.78 | MAPK1 (0.57) | SMN1; SMN2NPC1RAB9AL3MBTL1HPGD | |
| SCHEMBL1565611 | 0.76 | EPHX2 (0.52) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL1565387 | 0.76 | MAPT (0.52) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL2652656 | 0.75 | KMT2A (0.51) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL7130168 | 0.71 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL1565315 | 0.71 | GAA (0.49) | SMN1; SMN2NPC1RAB9AL3MBTL1TP53 | |
| SCHEMBL27760710 | 0.70 | NPC1 (0.59) | SMN1; SMN2NPC1RAB9AHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |