Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565387 | 0.93 | MAPT (0.52) | MAPTL3MBTL1PIK3CDPIK3C2BAURKA | |
| SCHEMBL1566677 | 0.83 | MAPT (0.51) | MAPTPIK3CDPIK3C2BAURKAPIK3C2G | |
| SCHEMBL2652222 | 0.83 | SMN1; SMN2 (0.49) | MAPTL3MBTL1CYP2C9ADORA2ASMN1; SMN2 | |
| SCHEMBL2654801 | 0.82 | MAPT (0.49) | MAPTL3MBTL1PIK3CDPIK3C2BAURKA | |
| SCHEMBL1565010 | 0.80 | SMN1; SMN2 (0.48) | L3MBTL1CYP2C9ADORA2ASMN1; SMN2NPC1 | |
| SCHEMBL1565764 | 0.79 | EPHX2 (0.50) | MAPTPOLB | |
| SCHEMBL10536299 | 0.77 | TSHR (0.48) | NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL2652656 | 0.76 | KMT2A (0.51) | L3MBTL1KDM4ESMN1; SMN2POLBNPC1 | |
| SCHEMBL10476874 | 0.76 | TSHR (0.51) | MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL2653444 | 0.73 | MAPK1 (0.57) | L3MBTL1MAPK1CDK5CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |