Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565820 | 0.86 | KMT2A (0.51) | KMT2ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL2653273 | 0.76 | MAPT (0.50) | KMT2ANPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2652222 | 0.75 | SMN1; SMN2 (0.49) | KMT2ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL2653444 | 0.73 | MAPK1 (0.57) | NPC1RAB9ASMN1; SMN2HPGDLMNA | |
| SCHEMBL1565010 | 0.72 | SMN1; SMN2 (0.48) | KMT2ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1565387 | 0.70 | MAPT (0.52) | KMT2ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL11934278 | 0.69 | BCHE (0.55) | KMT2ABCHEMEN1GRM2 | |
| SCHEMBL153840 | 0.69 | L3MBTL1 (0.54) | BCHEL3MBTL1 | |
| SCHEMBL2655095 | 0.69 | ALDH1A1 (0.48) | KMT2ANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL20978448 | 0.69 | BCHE (0.52) | KMT2ABCHEMEN1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |