Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.64 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.64 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.64 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.64 |
| ▸ | GCK | P35557 | 18/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653355 | 0.87 | GCK (0.58) | GCKKCNH2 | |
| SCHEMBL2652474 | 0.85 | GCK (0.73) | GCKKCNH2 | |
| SCHEMBL2651070 | 0.83 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2651431 | 0.78 | GCK (0.53) | GCKKCNH2 | |
| SCHEMBL2650224 | 0.78 | PLA2G2A (0.52) | GCKKCNH2 | |
| SCHEMBL2664611 | 0.76 | TSHR (0.72) | CHRNB2CHRNB4CHRNA3CHRNA4TSHR | |
| SCHEMBL944845 | 0.76 | GCK (0.60) | GCKKCNH2 | |
| SCHEMBL944606 | 0.75 | GCK (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4GCK | |
| SCHEMBL16473218 | 0.75 | GCK (0.81) | GCKKCNH2 | |
| SCHEMBL28079725 | 0.74 | GCK (0.72) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718625-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080360-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |