Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652479 | 0.87 | CHRNB2 (0.64) | GCKKCNH2 | |
| SCHEMBL2653351 | 0.85 | GCK (0.74) | GCKRXFP1KCNH2 | |
| SCHEMBL3608863 | 0.84 | GCK (0.64) | GCKKCNH2 | |
| SCHEMBL3595155 | 0.84 | GCK (0.70) | GCKKCNH2 | |
| SCHEMBL2651070 | 0.83 | GCK (0.55) | GCKKCNH2 | |
| SCHEMBL2651431 | 0.79 | GCK (0.53) | GCKCA12CA1CA9KCNH2 | |
| SCHEMBL2650224 | 0.79 | PLA2G2A (0.52) | GCKCA12CA1CA9KCNH2 | |
| SCHEMBL945735 | 0.75 | GCK (0.61) | GCKKCNH2 | |
| SCHEMBL15062252 | 0.75 | GCK (0.50) | GCKKCNH2 | |
| SCHEMBL1724732 | 0.75 | GCK (0.75) | GCKCA12CA1CA9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718625-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080360-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |