Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653842 | 0.85 | ALDH1A1 (0.38) | ALDH1A1LMNAHPGDMCL1PRSS1 | |
| SCHEMBL2654035 | 0.82 | HPGD (0.38) | ALDH1A1LMNAHPGDMAPTTSHR | |
| SCHEMBL2655622 | 0.74 | ALDH1A1 (0.45) | ALDH1A1LMNAHPGDTP53MAPT | |
| SCHEMBL6194559 | 0.73 | DAO (0.42) | ALDH1A1LMNAHPGDMRGPRX4TP53 | |
| SCHEMBL2653999 | 0.72 | FFAR1 (0.41) | GPR88MCL1TSHR | |
| SCHEMBL6196081 | 0.72 | DAO (0.41) | ALDH1A1LMNAHPGDMRGPRX4TP53 | |
| SCHEMBL2654239 | 0.72 | GCGR (0.41) | LMNATP53MAPTMCL1PRSS1 | |
| SCHEMBL2652978 | 0.71 | ALDH1A1 (0.41) | ALDH1A1LMNAHPGDMCL1PRSS1 | |
| SCHEMBL7013256 | 0.71 | ALDH1A1 (0.46) | ALDH1A1LMNAHPGDMRGPRX4TP53 | |
| SCHEMBL2654772 | 0.71 | GCGR (0.36) | MCL1PRSS1TMPRSS15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |