Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.33 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | GCG | P01275 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653883 | 0.88 | KMT2A (0.38) | KMT2AMCL1GCGRAKT3FOLR1 | |
| SCHEMBL2653999 | 0.88 | FFAR1 (0.41) | KMT2AMCL1GCGRFOLR1FFAR1 | |
| SCHEMBL2654239 | 0.87 | GCGR (0.41) | LMNAKMT2AMCL1GCGRFOLR1 | |
| SCHEMBL2653842 | 0.87 | ALDH1A1 (0.38) | ALDH1A1LMNAPRNPRECQLRXFP1 | |
| SCHEMBL2654772 | 0.85 | GCGR (0.36) | KMT2AMCL1GCGRFOLR1FFAR1 | |
| SCHEMBL2653953 | 0.85 | GCGR (0.43) | KMT2AMCL1GCGRFFAR1GCG | |
| SCHEMBL2655038 | 0.85 | GCGR (0.39) | LMNAKMT2AMCL1GCGRFFAR1 | |
| SCHEMBL2652676 | 0.84 | GCGR (0.51) | KMT2AMCL1GCGRFFAR1ACKR3 | |
| SCHEMBL2656326 | 0.84 | S1PR1 (0.38) | GCGRFFAR1ACKR3GCGS1PR1 | |
| SCHEMBL2654214 | 0.83 | GCGR (0.38) | HPGDKMT2AMCL1GCGRFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |