Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL195269 | 0.86 | KMT2A (0.46) | LMNAALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL14653954 | 0.80 | GAA (0.39) | LMNAALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL8190574 | 0.75 | LMNA (0.41) | LMNAALDH1A1KDM4ENPSR1KMT2A | |
| SCHEMBL8190573 | 0.75 | LMNA (0.41) | LMNAALDH1A1KDM4ENPSR1KMT2A | |
| SCHEMBL263894 | 0.75 | GAA (0.42) | LMNAALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL27966619 | 0.73 | KMT2A (0.47) | LMNAALDH1A1KDM4EGAANPSR1 | |
| Hydrochloric Acid SCHEMBL5847443 | 0.70 | LMNA (0.54) | LMNAALDH1A1KDM4EGAANPSR1 | |
| SCHEMBL13891162 | 0.69 | HTT (0.50) | LMNAALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL13891221 | 0.69 | HTT (0.50) | LMNAALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL27847954 | 0.69 | KMT2A (0.44) | LMNAALDH1A1KDM4EGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-8133994-B2 | Preparation of aprepitant | DR. REDDY'S LABORATORIES LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-20110094321-A1 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-04-28 | — | — | US | disclosed |
| US-20110094321-A1 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-04-28 | — | — | US | disclosed |
| US-20110094321-A1 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-04-28 | — | — | US | disclosed |
| EP-1942734-A2 | PREPARATION OF APREPITANT | Dr. Reddy's Laboratories Ltd. (IN) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007044829-A2 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044829-A2 | PREPARATION OF APREPITANT | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110094321-A1 | PREPARATION OF APREPITANT | KIT, CPA3, CMA1 | LMNA 2232/4885ALDH1A1 456/4885KDM4E 2494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.