Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.48 |
| ▸ | RXRG | P48443 | 8/20 | 0.48 |
| ▸ | RXRB | P28702 | 7/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269018 | 0.94 | RXRA (0.53) | RXRARXRGRXRBPIK3CAPSEN1 | |
| SCHEMBL4657783 | 0.89 | PIK3CA (0.50) | RXRARXRGRXRBPTPN1GSK3B | |
| SCHEMBL17634087 | 0.79 | GSK3B (0.56) | RXRARXRGRXRBPTPN1GSK3B | |
| SCHEMBL4305804 | 0.78 | PIK3CA (0.56) | RXRARXRGRXRBPTPN1GSK3B | |
| SCHEMBL2652603 | 0.77 | RXRA (0.56) | RXRARXRGRXRBPIK3CAPSEN1 | |
| SCHEMBL30628135 | 0.76 | PIK3CA (0.47) | RXRARXRGRXRBPIK3CAPSEN1 | |
| SCHEMBL2272003 | 0.75 | RXRA (0.77) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL11137241 | 0.75 | PTPN1 (0.57) | PTPN1GSK3BKIF11HDAC1HDAC8 | |
| SCHEMBL8425193 | 0.74 | BACE1 (0.54) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL2269889 | 0.74 | MAPT (0.61) | RXRARXRGRXRBPTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |