Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 13/20 | 0.77 |
| ▸ | RXRG | P48443 | 13/20 | 0.77 |
| ▸ | RXRB | P28702 | 12/20 | 0.77 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.71 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.71 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.71 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.71 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.71 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | PPARD | Q03181 | 3/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL267205 | 0.94 | RXRA (0.68) | RXRARXRGRXRBPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL2528774 | 0.92 | RXRA (0.66) | RXRARXRGRXRBPSEN1PSEN2 | |
| Water SCHEMBL28015733 | 0.92 | RXRA (0.66) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL491483 | 0.87 | RXRA (0.71) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL5464443 | 0.84 | RXRA (0.57) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL8329343 | 0.84 | LTA4H (0.60) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL18427891 | 0.83 | LMNA (0.86) | RXRARXRGRXRBABCC4LMNA | |
| SCHEMBL68027 | 0.83 | LMNA (0.86) | RXRARXRGRXRBABCC4LMNA | |
| SCHEMBL6267349 | 0.83 | PSEN1 (0.64) | RXRARXRGRXRBPSEN1PSEN2 | |
| SCHEMBL4597847 | 0.83 | PSEN1 (1.00) | RXRARXRGRXRBPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020040326-A1 | PHENYLACETIC ACID DERIVATIVE, AND COMPOSITION FOR PREVENTING OR TREATING AUTOIMMUNE DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT | 가천대학교 산학협력단 | 2020-02-27 | — | — | WO | disclosed |
| US-7989457-B2 | Used to treat diabetic and other glucagon related metabolic disorders such as obesity, hyperglycemia, atherosclerosis, ischemic heart disease, stroke, neuropathy, and wound healing; (R,S)-Methanesulfonic acid 2-(3-methyl-4'-trifluoromethyl-biphenyl-4-yl)-propyl ester | ELI LILLY AND COMPANY (US) | 2011-08-02 | — | — | US | disclosed |
| US-20080125468-A1 | Glucagon Receptor Antagonists, Preparation and Therapeutic Uses | ELI LILLY AND COMPANY | 2008-05-29 | — | — | US | disclosed |
| US-RE39916-E1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER LAMBERT COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| US-RE39916-E1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER LAMBERT COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| US-RE39916-E1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER LAMBERT COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |
| US-6964983-B2 | Compounds that modulate PPAR activity and methods for their preparation | WARNER-LAMBERT COMPANY, LLC (US) | 2005-11-15 | — | — | US | disclosed |
| US-6939875-B2 | Carbocyclic oxy sulfides such as [4-(Biphenyl-4-ylmethylsulfanyl)-5-methoxy-2-methyl-phenoxy]-acetic acid, used to control peroxisome proliferator activated receptors (PPAR), for prophylaxis of metabolic disorders | WARNER-LAMBERT COMPANY (US) | 2005-09-06 | — | — | US | disclosed |
| US-20050153996-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | AUERBACH BRUCE J (US) | 2005-07-14 | — | — | US | disclosed |
| US-20050113440-A1 | Compounds that modulate PPAR activity and methods for their preparation | AUERBACH BRUCE J (US) | 2005-05-26 | — | — | US | disclosed |
| EP-1494989-A2 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-12 | — | — | EP | disclosed |
| US-20040043904-A1 | N-(4-pyrazolyl) amide derivatives, chemicals for agricultural and horticultural use, and usage of the same | NIHON NOHYAKU CO., LTD. (JP) | 2004-03-04 | — | — | US | disclosed |
| US-20030225158-A1 | Compounds that modulate PPAR activity and methods for their preparation | WARNER-LAMBERT COMPANY | 2003-12-04 | — | — | US | disclosed |
| WO-2003084916-A2 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-16 | — | — | WO | disclosed |
| EP-1319657-A1 | N-(4-PYRAZOLYL)AMIDE DERIVATIVES, CHEMICALS FOR AGRICULTURAL AND HORTICULTURAL USE, AND USAGE OF THE SAME | Nihon Nohyaku Co., Ltd. (JP) | 2003-06-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225158-A1 | Compounds that modulate PPAR activity and methods for their preparation | GPR119, PPARA, PPARG | RXRA 68/4885RXRG 39/4885RXRB 71/4885 |
| US-20080125468-A1 | Glucagon Receptor Antagonists, Preparation and Therapeutic Uses | GLP1R, GCGR, GIPR | RXRA 571/4885RXRG 475/4885RXRB 565/4885 |
| US-20050113440-A1 | Compounds that modulate PPAR activity and methods for their preparation | GPR119, PPARA, PPARG | RXRA 68/4885RXRG 39/4885RXRB 71/4885 |
| US-20040043904-A1 | N-(4-pyrazolyl) amide derivatives, chemicals for agricultural and horticultural use, and usage of the same | CBR3, CYP8B1, CBR1 | RXRA 3562/4885RXRG 3550/4885RXRB 3816/4885 |
| US-20050153996-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS FOR THEIR PREPARATION | GPR119, PPARA, PPARG | RXRA 68/4885RXRG 39/4885RXRB 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.