Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 6/20 | 0.54 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | GCG | P01275 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | PTAFR | P25105 | 1/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651512 | 0.91 | GCG (0.51) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2651800 | 0.91 | CASP3 (0.53) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2651753 | 0.91 | GCG (0.49) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2653154 | 0.91 | GCG (0.53) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2651554 | 0.91 | SMN1; SMN2 (0.58) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2653041 | 0.90 | GCGR (0.49) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2651638 | 0.90 | GCGR (0.49) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2653579 | 0.90 | NPC1 (0.50) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2651583 | 0.90 | GCGR (0.49) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2652475 | 0.90 | GCGR (0.49) | S1PR1S1PR3S1PR5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | claimed |
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |