Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652509 | 0.96 | MEN1 (0.56) | MEN1KMT2AMAPTCYP4A11CYP4F2 | |
| SCHEMBL2652371 | 0.86 | PLA2G4B (0.56) | MEN1KMT2AMAPTMAOB | |
| SCHEMBL2652734 | 0.84 | MEN1 (0.57) | MEN1KMT2AMAPTMAOBRAB9A | |
| SCHEMBL2653250 | 0.84 | MEN1 (0.57) | MEN1KMT2AMAPTMAOBRAB9A | |
| SCHEMBL2653634 | 0.83 | MEN1 (0.49) | MEN1KMT2AMAOBRAB9APPARA | |
| SCHEMBL2654466 | 0.83 | MEN1 (0.56) | MEN1KMT2AMAPTMAOBRAB9A | |
| SCHEMBL2653990 | 0.83 | MEN1 (0.56) | MEN1KMT2AMAPTMAOBRAB9A | |
| SCHEMBL2652217 | 0.83 | BCL2 (0.54) | MEN1KMT2AMAOBPPARAPPARD | |
| SCHEMBL2653079 | 0.83 | BCL2 (0.54) | MEN1KMT2AMAOBPPARAPPARD | |
| SCHEMBL15437084 | 0.82 | CYP4A11 (0.58) | MAPTCYP4A11CYP4F2MAOBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |