Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | RARB | P10826 | 7/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652217 | 1.00 | BCL2 (0.54) | BCL2MEN1KMT2ARARBSRD5A2 | |
| SCHEMBL2652371 | 0.96 | PLA2G4B (0.56) | BCL2MEN1KMT2ARARBSRD5A2 | |
| SCHEMBL2653107 | 0.87 | SMN1; SMN2 (0.59) | MEN1KMT2ASRD5A2MAOBNR4A2 | |
| SCHEMBL2652509 | 0.86 | MEN1 (0.56) | MEN1KMT2AMAOBPPARDPPARA | |
| SCHEMBL2652593 | 0.84 | MEN1 (0.57) | MEN1KMT2AFFAR1FFAR4 | |
| SCHEMBL2653326 | 0.84 | MEN1 (0.57) | MEN1KMT2AFFAR1FFAR4 | |
| SCHEMBL2654154 | 0.83 | SMN1; SMN2 (0.60) | RARBPLA2G4BMRGPRX4PPARDPPARA | |
| SCHEMBL28024642 | 0.83 | SRD5A2 (0.68) | MEN1KMT2ARARBSRD5A2 | |
| SCHEMBL2652878 | 0.83 | MEN1 (0.55) | MEN1KMT2AMAOBPPARDPPARA | |
| SCHEMBL2652916 | 0.82 | GCGR (0.52) | MEN1KMT2AMAOBPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |