Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | GIPR | P48546 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655337 | 0.90 | GCGR (0.51) | MEN1KMT2AGCGRGIPRMAPK14 | |
| SCHEMBL2651132 | 0.86 | GCGR (0.52) | MEN1KMT2AGCGRGIPRMAOB | |
| SCHEMBL2652916 | 0.86 | GCGR (0.52) | MEN1KMT2AGCGRGIPRMAOB | |
| SCHEMBL2652878 | 0.83 | MEN1 (0.55) | MEN1KMT2AMAOBRAB9ANAAA | |
| SCHEMBL2653990 | 0.82 | MEN1 (0.56) | MEN1KMT2AMAOBMAPK14NPC1 | |
| SCHEMBL2654466 | 0.82 | MEN1 (0.56) | MEN1KMT2AMAOBMAPK14NPC1 | |
| SCHEMBL2652734 | 0.81 | MEN1 (0.57) | MEN1KMT2AMAOBMAPK14NPC1 | |
| SCHEMBL2653250 | 0.81 | MEN1 (0.57) | MEN1KMT2AMAOBMAPK14NPC1 | |
| SCHEMBL2652509 | 0.80 | MEN1 (0.56) | MEN1KMT2AMAOBNPC1RAB9A | |
| SCHEMBL2661613 | 0.80 | MEN1 (0.55) | MEN1KMT2AGCGRGIPRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |