Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 14/20 | 0.61 |
| ▸ | IMPDH1 | P20839 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24131979 | 0.90 | IMPDH2 (0.53) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL22170244 | 0.89 | IMPDH2 (0.58) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL24131913 | 0.88 | IMPDH2 (0.52) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL24131978 | 0.88 | IMPDH2 (0.52) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL24131941 | 0.82 | IMPDH2 (0.53) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL24131943 | 0.81 | IMPDH2 (0.48) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL24131959 | 0.80 | IMPDH2 (0.53) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL29454982 | 0.79 | MAOB (0.68) | IMPDH2IMPDH1ROCK2ROCK1 | |
| SCHEMBL22158319 | 0.79 | MAOB (0.68) | IMPDH2IMPDH1ROCK2ROCK1 | |
| SCHEMBL30292055 | 0.79 | MAOB (0.68) | IMPDH2IMPDH1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322749-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | ENDOGENA THERAPEUTICS, INC. (US) | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230322749-A1 | NEW COMPOUNDS AND THEIR USE AS THERAPEUTICALLY ACTIVE SUBSTANCES IN THE TREATMENT AND/OR PREVENTION OF DISEASES INVOLVING THE RETINAL PIGMENT EPITHELIUM | ALDH1A2, NR2E3, RB1 | IMPDH2 4176/4885IMPDH1 4302/4885ROCK2 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.