Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 9/20 | 0.52 |
| ▸ | GIPR | P48546 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | GLP1R | P43220 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651132 | 1.00 | GCGR (0.52) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2655337 | 0.96 | GCGR (0.51) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2653634 | 0.86 | MEN1 (0.49) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2652593 | 0.83 | MEN1 (0.57) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2653326 | 0.83 | MEN1 (0.57) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2652217 | 0.82 | BCL2 (0.54) | MEN1KMT2APPARDPPARAMAOB | |
| SCHEMBL2653079 | 0.82 | BCL2 (0.54) | MEN1KMT2APPARDPPARAMAOB | |
| SCHEMBL2652509 | 0.81 | MEN1 (0.56) | MEN1KMT2ANPC1RAB9APPARG | |
| SCHEMBL2655721 | 0.80 | MEN1 (0.56) | GCGRGIPRMEN1KMT2AMAPK14 | |
| SCHEMBL2651906 | 0.80 | MEN1 (0.56) | GCGRGIPRMEN1KMT2AMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |