Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.43 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22607908 | 0.91 | MRGPRX4 (0.40) | CYP4A11CYP4F2MRGPRX4OPRD1HPGD | |
| SCHEMBL2654739 | 0.84 | DAO (0.52) | MRGPRX4TSHRALDH1A1KDM4EDAO | |
| SCHEMBL7836036 | 0.83 | CYP4A11 (0.44) | CYP4A11CYP4F2OPRD1HPGDL3MBTL1 | |
| SCHEMBL22607818 | 0.83 | MRGPRX4 (0.39) | MRGPRX4OPRD1HPGDL3MBTL1MAPK1 | |
| SCHEMBL23022514 | 0.80 | CSNK2A2 (0.41) | CYP4A11CYP4F2MRGPRX4OPRD1HPGD | |
| SCHEMBL22607885 | 0.78 | MRGPRX4 (0.39) | MRGPRX4OPRD1HPGDL3MBTL1MAPK1 | |
| SCHEMBL22607939 | 0.74 | MRGPRX4 (0.31) | MRGPRX4HPGDALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL22624629 | 0.73 | MRGPRX4 (0.36) | MRGPRX4HPGDL3MBTL1MAPK1TSHR | |
| SCHEMBL22607895 | 0.73 | USP2 (0.47) | CYP4A11CYP4F2OPRD1HPGDL3MBTL1 | |
| SCHEMBL23013272 | 0.72 | HTR4 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |