Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 5/20 | 0.52 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653080 | 0.84 | CYP4A11 (0.43) | DAOALDH1A1KDM4EKMT2ATSHR | |
| SCHEMBL23013214 | 0.82 | DAO (0.59) | DAOGPR35GSK3BALDH1A1KDM4E | |
| SCHEMBL25547089 | 0.81 | DAO (0.53) | DAOGPR35GSK3BALDH1A1KDM4E | |
| SCHEMBL8805459 | 0.79 | DAO (0.52) | DAOGPR35ALDH1A1KDM4EMEN1 | |
| SCHEMBL22607908 | 0.73 | MRGPRX4 (0.40) | DAOGSK3BALDH1A1KDM4EMAPT | |
| SCHEMBL23013236 | 0.71 | DAO (0.50) | DAOALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL22607817 | 0.69 | DAO (0.41) | DAOALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL788050 | 0.69 | DAO (1.00) | DAOGPR35GSK3BALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL8935127 | 0.67 | DAO (0.95) | DAOGPR35GSK3BALDH1A1KDM4E | |
| SCHEMBL18701713 | 0.67 | DAO (0.65) | DAOGPR35GSK3BALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |