Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 19/20 | 0.53 |
| ▸ | GIPR | P48546 | 5/20 | 0.47 |
| ▸ | GCG | P01275 | 2/20 | 0.44 |
| ▸ | GLP1R | P43220 | 2/20 | 0.43 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655051 | 0.93 | GCGR (0.55) | GCGRGIPRGCGGLP1RCHRM5 | |
| SCHEMBL2653285 | 0.92 | GCGR (0.45) | GCGRGIPRGLP1RVIPR2 | |
| SCHEMBL2656116 | 0.87 | GCGR (0.55) | GCGRGIPRGCGGLP1RCHRM5 | |
| SCHEMBL2655997 | 0.85 | GCGR (0.61) | GCGRGCG | |
| SCHEMBL2653527 | 0.84 | GCGR (0.55) | GCGRGIPRGCGGLP1RCHRM5 | |
| SCHEMBL2655857 | 0.84 | GCGR (0.46) | GCGRGCGGLP1RCHRM5 | |
| SCHEMBL2657436 | 0.82 | GCGR (0.54) | GCGRGIPR | |
| SCHEMBL2653639 | 0.82 | GCGR (0.56) | GCGRGIPRGCGGLP1RCHRM5 | |
| SCHEMBL2654697 | 0.81 | GCGR (0.55) | GCGRGIPRGCGGLP1RCHRM5 | |
| SCHEMBL12595504 | 0.80 | GCGR (0.57) | GCGRGIPRGCGGLP1RCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | claimed |
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |