Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 5/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.44 |
| ▸ | PPARG | P37231 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GCG | P01275 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656634 | 0.93 | GCGR (0.50) | GCGREPHX2MAPTSMN1; SMN2NPC1 | |
| SCHEMBL2655051 | 0.91 | GCGR (0.55) | GCGRGCGPPARAPPARDCHRM5 | |
| SCHEMBL2653285 | 0.87 | GCGR (0.45) | GCGRMAPTSMN1; SMN2NPC1PPARA | |
| SCHEMBL2654932 | 0.86 | GCGR (0.46) | GCGRMAPTGCGPPARAPPARD | |
| SCHEMBL2656547 | 0.84 | MAPT (0.48) | EPHX2MAPTSMN1; SMN2NPC1 | |
| SCHEMBL2653091 | 0.84 | GCGR (0.53) | GCGRGCGCHRM5GLP1R | |
| SCHEMBL2656116 | 0.83 | GCGR (0.55) | GCGRGCGPPARAPPARDCHRM5 | |
| SCHEMBL2655997 | 0.83 | GCGR (0.61) | GCGREPHX2GCGNPC1RAB9A | |
| SCHEMBL2655853 | 0.82 | GCGR (0.49) | GCGRMAPTSMN1; SMN2GCGNPC1 | |
| SCHEMBL2653527 | 0.82 | GCGR (0.55) | GCGRGCGPPARAPPARDCHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951659-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | Eli Lilly & Company (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007114855-A2 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |