Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.45 |
| ▸ | GIPR | P48546 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | VIPR2 | P41587 | 1/20 | 0.38 |
| ▸ | GLP1R | P43220 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653091 | 0.92 | GCGR (0.53) | GCGRGIPRVIPR2GLP1R | |
| SCHEMBL2654932 | 0.87 | GCGR (0.46) | GCGRGIPRMEN1KMT2AMAPT | |
| SCHEMBL2655857 | 0.87 | GCGR (0.46) | GCGRNPC1MAPTGLP1RPPARD | |
| SCHEMBL2655051 | 0.85 | GCGR (0.55) | GCGRGIPRGLP1RPPARDPPARA | |
| SCHEMBL2657426 | 0.83 | GCGR (0.46) | GCGRGIPRMAPTVIPR2GLP1R | |
| SCHEMBL2655056 | 0.81 | GCGR (0.47) | GCGRGIPRMEN1KMT2AMAPT | |
| SCHEMBL2657424 | 0.81 | GCGR (0.46) | GCGR | |
| SCHEMBL2654579 | 0.80 | PPARD (0.43) | GCGRGIPRMEN1KMT2ASPHK2 | |
| SCHEMBL2656116 | 0.80 | GCGR (0.55) | GCGRGIPRMEN1KMT2AGLP1R | |
| SCHEMBL2656001 | 0.80 | GCGR (0.51) | GCGRMEN1KMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |