Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 7/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GIPR | P48546 | 3/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GCG | P01275 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653953 | 0.88 | GCGR (0.43) | GCGRMCL1FFAR1GIPRKMT2A | |
| SCHEMBL2652221 | 0.88 | GCGR (0.50) | GCGRMCL1ALDH1A1LMNAPRNP | |
| SCHEMBL2652620 | 0.87 | GCGR (0.46) | GCGRMCL1GCG | |
| SCHEMBL2654422 | 0.87 | GCGR (0.49) | GCGRMCL1ALDH1A1LMNAPRNP | |
| SCHEMBL2654118 | 0.86 | FFAR4 (0.42) | GCGRMCL1FFAR1GIPR | |
| SCHEMBL2652586 | 0.86 | GCGR (0.45) | GCGRMCL1ALDH1A1LMNAPRNP | |
| SCHEMBL2653891 | 0.86 | GCGR (0.42) | GCGRMCL1GIPRKMT2AGCG | |
| SCHEMBL2654052 | 0.85 | GCGR (0.51) | GCGRMCL1ALDH1A1LMNAPRNP | |
| SCHEMBL2652922 | 0.84 | GCGR (0.46) | GCGRMCL1GCG | |
| SCHEMBL2652629 | 0.82 | GCGR (0.51) | GCGRMCL1FFAR1POLBGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |