Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.76 |
| ▸ | NPC1 | O15118 | 7/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | BRD4 | O60885 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | STAMBP | O95630 | 1/20 | 0.53 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14484091 | 0.91 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL29411040 | 0.89 | HPGD (0.66) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL12158613 | 0.86 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL31396767 | 0.86 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL2307879 | 0.86 | RAB9A (0.74) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL10442013 | 0.86 | NPC1 (0.74) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL10441846 | 0.86 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL10441735 | 0.85 | NPC1 (0.72) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL506838 | 0.84 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2TAAR1HPGD | |
| SCHEMBL12158622 | 0.84 | NPC1 (0.75) | RAB9ANPC1SMN1; SMN2TAAR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-02-27 | — | — | US | disclosed |
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-02-27 | — | — | US | disclosed |
| EP-3471723-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | Memorial Sloan Kettering Cancer Center (US) | 2019-04-24 | — | — | EP | disclosed |
| US-20180175309-A1 | ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2018-06-21 | — | — | US | disclosed |
| US-20180175309-A1 | ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2018-06-21 | — | — | US | disclosed |
| US-20160164007-A1 | ORGANIC METAL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2016-06-09 | — | — | US | disclosed |
| US-20160164007-A1 | ORGANIC METAL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME | INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE (TW) | 2016-06-09 | — | — | US | disclosed |
| EP-1891069-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4,5B]PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | AstraZeneca AB (SE) | 2008-02-27 | — | — | EP | disclosed |
| US-7230020-B2 | 11β-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2007-06-12 | — | — | US | disclosed |
| WO-2006125958-A1 | 2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |
| EP-1675844-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | Sterix Limited (GB) | 2006-07-05 | — | — | EP | disclosed |
| US-7019033-B2 | 2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives | WARNER-LAMBERT COMPANY (US) | 2006-03-28 | — | — | US | disclosed |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | STERIX LIMITED (GB) | 2005-10-13 | — | — | US | disclosed |
| WO-2005042513-A1 | PHENYL CARBOXAMIDE AND SULFONAMIDE DERIVATIVES FOR USE AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE | STERIX LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |
| EP-0367233-A2 | Process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof | OCCIDENTAL CHEMICAL CORPORATION (US) | 1990-05-09 | — | — | EP | disclosed |
| EP-0348505-A1 | NOVEL N-(1-THIENYLETHYL)AMINE DERIVATIVES AND HERBICIDES CONTAINING THE SAME AS EFFECTIVE INGREDIENT | DAIKIN INDUSTRIES, LIMITED (JP) | 1990-01-03 | — | — | EP | disclosed |
| US-4874876-A | ACYLATING THIOPHENE, REDUCING, HYDROLYZING | OCCIDENTAL CHEMICAL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180175309-A1 | ORGANOMETALLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME | C1S, C1R, C9 | RAB9A 2052/4885NPC1 3536/4885SMN1; SMN2 4481/4885 |
| US-20160164007-A1 | ORGANIC METAL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE EMPLOYING THE SAME | C5, C9, C1S | RAB9A 2241/4885NPC1 2159/4885SMN1; SMN2 4599/4885 |
| US-20050227987-A1 | 11beta-hydroxysteroid dehydrogenase inhibitors | HSD3B1, HSD3B2, HSD17B3 | RAB9A 3856/4885NPC1 1239/4885SMN1; SMN2 4243/4885 |
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | HHAT, SHH, MBOAT1 | RAB9A 1170/4885NPC1 235/4885SMN1; SMN2 4467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.