Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.48 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.48 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | FDFT1 | P37268 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266389 | 0.95 | ALDH1A1 (0.57) | MAOBALDH1A1FFAR1PDPK1PLAAT3 | |
| SCHEMBL2652762 | 0.90 | MAOB (0.45) | MAOBALDH1A1FFAR1PDPK1PLAAT3 | |
| SCHEMBL5182649 | 0.84 | HDAC1 (0.55) | MAOBALDH1A1FFAR1PDPK1PLAAT3 | |
| Benzylacetone SCHEMBL27750721 | 0.83 | ALDH1A1 (0.72) | ALDH1A1FFAR1PDPK1PLAAT3PLAAT5 | |
| SCHEMBL3634320 | 0.83 | MAOB (0.59) | MAOBFFAR1PDPK1PLAAT3PLAAT5 | |
| SCHEMBL2652603 | 0.82 | RXRA (0.56) | MAOBKIF11HRH3HDAC1HDAC8 | |
| SCHEMBL11638365 | 0.81 | HDAC1 (0.56) | ALDH1A1FFAR1PDPK1TAAR1MAPT | |
| SCHEMBL12126626 | 0.80 | ALDH1A1 (0.61) | ALDH1A1FFAR1MAPTHDAC8RXRA | |
| SCHEMBL7332151 | 0.80 | FFAR1 (0.57) | MAOBFFAR1PDPK1PLAAT3PLAAT5 | |
| SCHEMBL10912165 | 0.79 | ALDH1A1 (0.77) | ALDH1A1FFAR1MAPTHDAC1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |