Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | GCG | P01275 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656017 | 0.92 | S1PR1 (0.53) | HRH3KMT2AALDH1A1S1PR1MEN1 | |
| SCHEMBL2656425 | 0.91 | HRH3 (0.44) | HSD17B10HRH3KMT2ANPC1RAB9A | |
| SCHEMBL2654669 | 0.88 | CA1 (0.46) | HRH3KMT2ANPC1RAB9APLA2G4B | |
| SCHEMBL2654574 | 0.88 | GCG (0.57) | HRH3KMT2ANPC1RAB9APLA2G4B | |
| SCHEMBL2655431 | 0.88 | EPHX2 (0.47) | HRH3PLA2G4BS1PR1 | |
| SCHEMBL2654996 | 0.86 | FFAR1 (0.48) | HRH3KMT2ANPC1RAB9APLA2G4B | |
| SCHEMBL2654485 | 0.84 | NPC1 (0.47) | HRH3KMT2ANPC1RAB9APLA2G4B | |
| SCHEMBL2655347 | 0.83 | HPGD (0.43) | HRH3KMT2ANPC1RAB9APLA2G4B | |
| SCHEMBL2655574 | 0.83 | HRH3 (0.48) | HRH3PLA2G4BS1PR1 | |
| SCHEMBL2653359 | 0.83 | S1PR1 (0.55) | HSD17B10HRH3KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |