Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.53 |
| ▸ | RARB | P10826 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RARA | P10276 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 4/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653397 | 0.92 | HSD17B10 (0.49) | S1PR1RARBMEN1ALDH1A1RARA | |
| SCHEMBL2654669 | 0.88 | CA1 (0.46) | MEN1ALDH1A1MAPTKMT2AHRH3 | |
| SCHEMBL2654574 | 0.88 | GCG (0.57) | S1PR1RARBMEN1ALDH1A1MAPT | |
| SCHEMBL2655431 | 0.88 | EPHX2 (0.47) | S1PR1HRH3GCGR | |
| SCHEMBL2654996 | 0.86 | FFAR1 (0.48) | ALDH1A1KMT2AHRH3 | |
| SCHEMBL2656425 | 0.85 | HRH3 (0.44) | MEN1ALDH1A1MAPTKMT2AHRH3 | |
| SCHEMBL15723432 | 0.85 | RARB (0.61) | S1PR1RARBMEN1ALDH1A1RARA | |
| SCHEMBL13418360 | 0.85 | S1PR1 (0.65) | S1PR1RARBMEN1ALDH1A1KMT2A | |
| SCHEMBL7740315 | 0.84 | S1PR1 (0.62) | S1PR1RARBMEN1ALDH1A1RARA | |
| SCHEMBL2654485 | 0.84 | NPC1 (0.47) | KMT2AHRH3GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |